Santai SepaBean Automated Flash Instrument

The SepaBean machine is an innovative flash chromatography instrument designed specifically with the chemist in mind. Its unique user-friendly software interface allows seamless data collection and sharing as well as remote access.

  • Wireless Operation Through Mobile Devices
    The flexible wireless control method is especially suitable for separation experiments that need to be protected from light or placed in an isolator.
  • Power Failure Recovery
    The built-in power-off recovery function in the software minimises the loss caused by accidental power failure.
  • Smart Column Holder
    Column holder with touchpad could achieve automatic fixing of the flash column.*
  • Fraction Collector
    Tube racks with LCD enable users to track the tubes containing collected fractions quickly.
  • Separation Method Recommendation
    The software has a built-in separation method database that automatically recommends the most appropriate separation method based on the user’s information, thereby improving work efficiency.
  • Local Network Data Sharing
    Multiple instruments could form a local area network to facilitate internal data sharing and resource optimisation in the laboratory.
  • 21-CFR Part 11 Compliance
    The control software complies with FDA requirements for system safety (21-CFR Part 11), making the instrument more suitable for pharmaceutical R&D companies and laboratories.


*Smart column holder is not applicable for SepaBeanTM machine U.

With the new TLC-to-Gradient feature built into the control software of the SepaBean machine, the whole sample preparation process can be accelerated. Once you have entered the TLC information and sample load, the software will automatically recommend the best flash column for the separation, and the optimised elution gradient will be generated.

For reversed-phase separation, the control software can also assist the user with smart recommendations. Input the analytical HPLC information, including the retention time of the sample, the percentage of Solvent B when the specific component is eluted out, the peak area of the target product and the primary impurities, the elution gradient will be automatically generated.

Safe Reliable Data Recording & Sharing
All data generated by the SepaBean machine is stored and transmitted by 128/256 bit AES encryption technology and fully controlled by the owner of the machine.

Network ready, multiple instruments within an organisation can form a private channel. Users can share Separation methods across the entire organisation; authorised researchers can access and run these methods directly without re-developing the methods.

Discover and connect to peer instrument automatically. Once multiple instruments are connected, data is automatically synchronised, researchers can access their methods on any connected instrument from any location.

  • Models
  • Eco-friendly Column Management
  • Simple Mobile Interface
  • Internal Method Database
  • Global Chemistry Database
  • Technical Data
  • Quote


SepaBean® machine U
Entry-level model with all the features of SepaBean control software. Meet the demands of daily separation and purification, including normal phase and reversed-phase separation.

SepaBean® machine T
Cost-effective model with all features of SepaBean control software. Binary gradient with any combinations of two solvents. Optional ELSD to cover more types of samples.

SepaBean® machine
Standard version. Binary gradient with four solvent lines, high-pressure mixing.Optional ELSD to cover more types of samples.

SepaBean® machine 2
Medium pressure model which could perfectly match with SepaFlash spin-welded columns for higher separation efficiency. Binary gradient with any combinations of two solvents, 3rd solvent as a modifier, able to run complex separation conditions. Optional ELSD to cover more types of samples.

NEW SepaBean® machine 2S
Improved medium pressure model with a higher flow rate, up to 300 mL/min.
Binary gradient with any combinations of two solvents, 3rd solvent as a modifier, able to run complex separation conditions. Optional ELSD to cover more types of samples.

NEW SepaBean® machine L
High flow rate model for a large amount of sample purification (1000 ml/min & 150psi), up to 300 grams in a single run. Binary gradient with any combination of two solvents.

Eco-friendly Column Management

With RFID column reading technology the SepaBean Machine can record and manage the usage of each MODUS Flash column enabling users to efficiently re-use flash columns and dispose in an environmentally friendly way when the column has reached its end of life.

Simple Mobile Interface

The SepaBean Machine employs the most advanced control technology and utilizes an iPad for the interface. The software comes with a lifetime of free updates which can easily be downloaded by the user from the APP store. The use of the iPad allows users to remotely access and control the machine even while in another room allowing chemists to maximize their laboratory time, the portable interface lets you get on with other work while still easily keeping an eye on your runs progress.

Internal Method Database

Researchers worldwide spend 1000’s of hours and numerous resources to develop methods of separating and purifying compound mixtures, including mixtures or extracts from natural products. These methods are usually stored in a single isolated location, disconnected from team members, and become "information islands". Unlike traditional flash instruments, SepaBean features a centralised, secure database and distributed computing technology to retain and share these methods across a secured organisational network:

With the built-in relational database to store separation methods, researchers can query existing or update new separation methods using the compound name, structure or project code.

Global Chemistry Database

When paired with the ChemBeanGo global database the built in method database can grow exponentially. ChemBeanGo encourages researches around the world to contribute their knowledge and experience to be freely accessed with other users around the globe.

Technical Data

Sample Weight mg up to 150g
Supported Column Size 4g - 1600g
Pump Binary maintenance-free Pumps
Flow Rate 1 - 200 mL/min
Flow Accuracy +/- 11%
Max Pressure 200 psi
Detector Dual-wavelength UV/VIS
Pump Gradient Linear, Step, Gradient
Software Lifetime software update via the App Store
Dimensions (H x W x D) 62cm X 40cm X 40cm


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